Lore
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Lore is often used to refer to the "backstory" of games and other settings. It is the collective history and events that create the setting for the world you play in.
History
Cataclysm DDA takes place in the New England region of the USA sometime in the 2040s. The game begins (on the default setting) five days after an event called the "Cataclysm" which destroyed civilization as we know it and replaced it with a new survival of the fittest scenario where roving criminal gangs are the least of your worries. The Cataclysm itself had been brewing for days, if not months before the day the world ended, but few were observant enough to see he dangers approaching through government cover ups.
See also:
Factions
There are countless factions patrolling the wastes of the old world, from the relatively benign to the absolutely hostile and from Human to things that were never meant to exist in this world.
Human
Many of the humans that survived the Cataclysm went solo, caring only for them selves, however, many others joined (or were already part of) the major factions that have arisen in this new world. They are:
XE037
XE037, or "the blob" as it is also known, is a diffuse, sentient extra-dimensional organism fist discovered by XEDRA researchers. Extremely adaptable, but finding Earth conditions to be hostile to its native form, it has adapted as best it can and is the most wide spread of all factions vying for dominance over Earth, but its victory is not guaranteed.
In their course of investigations, XEDRA scientists found out that the blob can alter the phenotype of individuals who it has parasitized. They used this knowledge to develop a wide range of Mutagens, many of which are no longer in their control.
Various forms that XE037 takes:
Mycus
A vast collective fungal intelligence, the Mycus was a species wholly unknown to XEDRA scientists before the Cataclysm. Unlike the blob, the Mycus found Earth to be a relatively habitable planet and has rapidly spread out across the surface, sending its spores high into the atmosphere, determined to colonize and "terraform" the planet before it falls into the hands of any of its rivals.